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The CagriSema metabolic preservation mechanism, specifically the maintenance of mitochondrial function in skeletal muscle during weight loss, could theoretically slow the rate of weight regain by preventing some of the metabolic adaptation that makes regain almost inevitable

doi: 10.1136/jitc-2021-004378 236 AwwadHMOhlmannCHStoeckleMAzizRGeiselJObeidR

Research consistently shows that resistance training during caloric restriction significantly reduces lean mass loss compared to caloric restriction alone

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